Having missed the bulk of 2006 with a chronic knee injury, Serena won the Australian Open as the world No. 81. Top-ranked Justine Henin edged her in three sets to take their London quarterfinal, however.
Hopes for a three-peat were dashed by Marion Bartoli in the round of 16. Given Serena had overcome a pulmonary embolism just months prior, simply having her back on the major stage was a victory in itself.