The world No. 1 aims to extend a 21-match win streak at hard-court majors—and renew his rivalry with Carlos Alcaraz—in Flushing Meadows.

Here’s a look at their respective paths, who might stand in their way, and who else is worth watching as the US Open begins.

Sincaraz could be the first duo since Roger Federer and Rafael Nadal in 2008 to compete in three Grand Slam finals in one season.